The key differences between the replication and transcription should be known first to proceed with the actual processes.
Theses are:
Type of nucleic acids differs.
Lengths of nucleic acids differ.
Enzymes involved are different (DNA polymerases/RNA polymerases).
Phases of cell cycle are different.
The Cell Cycle
Different phases of the cell cycle can be identified and understood with the help of the diagram. The is very helpful in understanding the coming topics.
Comparsion between Gene expression and Replication
GENE EXPRESSION
Produces all the proteins an organism requires. This process differs between different tissues.
Transcription DNA: RNA copy of small section of a chromosome (average human gene size is 104-105).
Transcription occurs in nucleus throughout the interphase.
Translation of RNA occurs in the cytoplasm throughout the cell cycle.
DNA REPLICATION
Duplicates the chromosomes before cell division. It is same for all tissues.
DNA makes a copy of the entire chromosome. (Average size of human chromosomes, 108 nucleotide pairs).