What are the Most Important Growth Hormone Abnormalities?

The Biochemistry Online – Free Online Lectures for Medical, Dental and Allied Health Sciences students by the Biochemistry Club.

Abnormalities of Growth Hormone

  • Excess secretion by Growth Hormone secreting tumor before adolescence, leads to Gigantism.
  • After adolescence – Acromegaly.
  • Deficiency in early childhood results in pituitary Dwarfism.
  • Deficiency in adults causes –NOTHING.


  • Gigantism is a Growth hormone abnormality caused by excessive secretion of Growth hormone before adolescence.
  • Excessive activation of cells, or tumor in the Anterior Pituitary results in rapid growth in all tissues including bones.
  • As a result the person becomes a giant; may grow up to 8 feet tall.
  • There is hyperglycemia leading to Diabetes mellitus. 
  • This is caused by secretion of excessive amount of Insulin to meet the requirement and ultimately the Beta cells of Pancreas burn out.
  • Pan-hypopituitarism eventually develops as the tumour invades the surrounding tissue resulting in destruction of other pituitary cells.
  • Death occurs if untreated.
All these lectures are organized and listed in detail in their proper sections. To view these lessons please visit the Hormones and Signal Transduction Section in Biochemistry II. This can be approached by directly clicking the Biochemistry II button or it can also be approached from the drop down menu in Biochemistry II tab. Once you reach the section click the curriculum tab to view the full list in the section.
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