What are the Most Important Differences between Rickets & Osteomalacia?

The Biochemistry Online – Free Online Lectures for Medical, Dental and Allied Health Sciences students by the Biochemistry Club.


  1. Rickets occurs in children due to Vitamin D deficiency.
  2. There is insufficient mineralization of bones, soft pliable bones, bone growth markedly affected.
  3. There is low plasma calcium & phosphorus.
  4. Alkaline Phosphatase is markedly raised.
  5. There are bone deformities like bow legs, knock-knees, rickety rosy, bossing of frontal bones & Pigeon chest.
  6. Enlargement of epiphysis at the lower end of the ribs & costochondral junction leads to Rickety Rosary.
  7. Harrison’s Sulcus is a transverse depression passing outwards from costal cartilage to axilla.


  1. Osteomalacia occurs in adults due to Vitamin D deficiency.
  2. Bones are softened due to insufficient mineralization & increased osteoporosis.
  3. Serum Alkaline phosphatase is increased.
  4. The serum calcium is slightly low along with low serum phosphate.
  5. Vitamin D deficiency never produces severe hypocalcemia.
  6. Tetany is not manifested.
  7. Patients are more prone to fractures.
All these lectures are organized and listed in detail in their proper sections. To view these lessons please visit the Vitamins Section in Biochemistry I. This can be approached by directly clicking the Biochemistry I button or it can also be approached from the drop down menu in Biochemistry I tab. Once you reach the section click the curriculum tab to view the full list in the section.
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