The Biochemistry Online – Free Online Lectures for Medical, Dental and Allied Health Sciences students by the Biochemistry Club.
ABNORMALITIES OF THYROID FUNCTION
- Goiter – Enlargement of thyroid gland.
- Euthyroid goiter – diffuse enlargement.
- Nodular goiter which may lead to hyperfunction, or
- Iodine deficiency goiter which may result in hypothyroidism.
Hyperthyroidism may be due to:
- Increase in binding protein & Increased affinity of binding protein
- Effects of autoantibodies
- TSH secreting tumors and
- T4 toxicosis (T4 increase; T3 low)
SYMPTOMS OF HYPERTHYROIDISM
- Increased rate of metabolism
- Weight loss
- Fine tremors
- Emotional disturbances
- Anxiety and
- Sensitivity to heat
CAUSES OF HYPERTHYROIDISM
- Toxic goiter
- Graves’ disease
- Excess intake of thyroid hormones
- Rarely, TSH secreting tumors of pituitary
It is due to the diseases of the Thyroid gland. It is seen in:
- Grave’s disease
- Toxic multinodular goiter
- Toxic adenoma
- Functioning metastatic thyroid carcinoma
- TSH receptor mutation
- Struma ovarii (teratomas of ovary),
- Iodine excess
It is due to diseases of pituitary or hypothalamus.
Will be discussed later …