The Most Important Role of Iodine in T.H. Synthesis?

The Biochemistry Online – Free Online Lectures for Medical, Dental and Allied Health Sciences students by the Biochemistry Club.

Role of Iodine in Thyroid Hormone Synthesis

  • Iodine is plays a very important role on the synthesis of the Thyroid hormones.
  • Without iodine (when there is deficiency) the thyroid hormones cannot be synthesized.
  • Requirement of iodine is about 150–200 mg/day.
  • Sources of iodine are drinking water, fish, cereals, vegetables & iodinated salt.
  • Total body contains 25–30 mg of iodine
  • 80% of the total iodine is stored in the thyroid gland.
  • The Iodine level in blood is 5–10 μg/dl.
  • Goitrogens are seen in cassava, maize, millet, bamboo shoots, sweet potatoes and beans.
  • Cabbage and tapioca contain thiocyanate, which inhibits iodine uptake by thyroid.
  • Mustard seed contains thiourea, which inhibits iodination of thyroglobulin.
  • The only biological role of iodine is in formation of thyroid hormones, thyroxine (T4) and tri-iodo thyronine  (T3).
All these lectures are organized and listed in detail in their proper sections. To view these lessons please visit the Hormones and Signal Transduction Section in Biochemistry II. This can be approached by directly clicking the Biochemistry II button or it can also be approached from the drop down menu in Biochemistry II tab. Once you reach the section click the curriculum tab to view the full list in the section.
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