Hypothalamic & Pituitary Hormones – Endocrine control
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Hypothalamus → Pituitary
- GnRH → FSH
- CRH → ACTH
- TRH → TSH
- GHRH → GH
- PIF → Prolactin inhibition
- ADH-Antidiuretic Hormone (Vasopressin)
Hypothalamic & Pituitary Hormones
Hypothalamus produces 2 types of endocrine factors:
- Hypothalamic neuropeptides
- Hypothalamic releasing factors
1. Hypothalamic Neuropeptides
Produced by the supraoptic and paraventricular nuclei (hypothalamus)
These neurohormones are:
- Antidiuretic Hormone (ADH)
* the precursors are long polypeptides
They are synthesized in hypothalamus.
Cleaved into the active molecule, and
Transported to posterior pituitary & stored there.
These are classified as Hormones of Posterior pituitary.
They are released to bloodstream by exocytosis.
2. Hypothalamic Releasing Factors
The releasing factors are neurosecretions synthesized in the hypothalamus and released through the hypothalamic pituitary portal circulation.
They affect the secretion of pituitary tropic hormone.