Deficiency of Vitamin D (Calcitriol)
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Causes of Vitamin D Deficiency
- Lack of exposure to sunlight. Most common in Muslim women who observe ‘Pardah’.
- Malabsorption of Vitamin D (Obstructive Jaundice, Steatorrhea).
- Abnormality of Vitamin D activation mostly in liver & renal diseases.
- Deficient renal absorption of phosphates.
- Nutritional deficiency of Calcium or phosphate may produce similar picture.
Consequences of Vitamin D Deficiency
Deficiency of Vitamin D may cause:
- Renal Osteodystrophy
- It is the clinical manifestation of Vitamin D deficiency in children.
- There is under mineralization of bones in children due to less absorption of calcium.
- There is continued formation of the collagen matrix of bone, but incomplete mineralization, resulting in soft, pliable and bowing of bones.
- Osteomalacia is the clinical manifestation of Vitamin D deficiency in adults.
- It results from demineralization of bone.
- Picture shows bowed legs of a man with Vitamin D deficiency which results in malformation of the skeleton.