Biochemistry- What are the Most Important Signs?-Cushing’s Syndrome.

Cushing’s Syndrome

Adrenal Hypersecretion

Difference between Cushing’s Syndrome and Cushing’s Disease

  • Hyperactivity of adrenal cortex may be due to primary defect in adrenal gland itself is called as the Cushing’s Syndrome.
  • While Cushing’s Disease is produced by excessive production of ACTH from pituitary or ectopic ACTH production by other malignant tumors.

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Cushing’s Syndrome presents with the following symptoms and signs. These symptoms and signs become more and more significant as the disease progresses and if not treated.


  • Central weight gain
  • Change in appearance
  • Depression
  • Amenorrhea / oligomenorrhea
  • Poor libido
  • Thin skin / easy bruising
  • Hair growth / acne
  • Muscular weakness
  • Growth arrest in children
  • Back pain
  • Polyuria, polydipsia
  • Psychosis


  • Moon face
  • Plethora
  • Depression / psychosis
  • Acne hirsutism frontal balding in females
  • Thin skin
  • Bruising
  • Poor wound healing
  • Pigmentation
  • Skin infections
  • Hypertension
  • Osteoporosis
  • Pathological fractures (especially in vertebrae and ribs)
  • Kyphosis
  • ‘Buffalo hump’ – dorsal fat pad
  • Central obesity
  • Striae (purple or red)
  • Rib fractures
  • Oedema
  • Proximal myopathy
  • Proximal muscle wasting
  • Glycosuria

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