Difference between Cushing’s Syndrome and Cushing’s Disease
- Hyperactivity of adrenal cortex may be due to primary defect in adrenal gland itself is called as the Cushing’s Syndrome.
- While Cushing’s Disease is produced by excessive production of ACTH from pituitary or ectopic ACTH production by other malignant tumors.
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Cushing’s Syndrome presents with the following symptoms and signs. These symptoms and signs become more and more significant as the disease progresses and if not treated.
- Central weight gain
- Change in appearance
- Amenorrhea / oligomenorrhea
- Poor libido
- Thin skin / easy bruising
- Hair growth / acne
- Muscular weakness
- Growth arrest in children
- Back pain
- Polyuria, polydipsia
- Moon face
- Depression / psychosis
- Acne hirsutism frontal balding in females
- Thin skin
- Poor wound healing
- Skin infections
- Pathological fractures (especially in vertebrae and ribs)
- ‘Buffalo hump’ – dorsal fat pad
- Central obesity
- Striae (purple or red)
- Rib fractures
- Proximal myopathy
- Proximal muscle wasting
All these lectures are organized and listed in detail in their proper sections. To view these lessons please visit the Hormones & Signal Transduction Section. This can be approached by directly clicking the Biochemistry II button or it can also be approached from the drop down menu in Biochemistry II tab. Once you reach the section click the curriculum tab to view the full list in the section.
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