Biochemistry of Vitamins: Important facts about the B Complex group-Thiamine (Vitamin B1).

Thiamine: Vitamin B1, Anti Beriberi factor, Aneurine.

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Thiamine-Vitamin B1

The B Complex Group

  • The vitamins  in the B Complex group are chemically not related to one another. 
  • They are grouped together because all of them function in the cells as Coenzymes
  • The important vitamins in the B Complex group are:
    1. Thiamine, 
    2. Riboflavin, 
    3. Niacin, 
    4. Pyridoxine,
    5. Pantothenic acid, 
    6. Biotin, 
    7. Folic acid and
    8. Vitamin B12.
  • A few others such as Choline, Inositol, Lipoic acid and para amino benzoic acid (PABA) were also included in this group. 
  • Although they have important functions inside the body but they cannot be considered as vitamins because, they are available in plenty. 
  • PABA is not a vitamin for higher species, but it is required by bacteria for synthesis of folic acid.

Thiamine (Vitamin B1)

Thiamine is also called as VitaminB1.

It is also known as Aneurine (it can relieve neuritis) or Anti Beriberi factor.

Sources of Thiamine

  • Aleurone layer of cereals (food grains) is a rich source of thiamine. 
  • When the grains are polished, aleurone layer is usually removed. 
  • Therefore, whole wheat flour and unpolished rice have better nutritive value than completely polished refined foods. 
  • Yeast is also a very good source. 
  • Thiamine is partially destroyed by heat.

Structure of Thiamine

  • Thiamine contains a  Pyrimidine ring connected to a Thiazole ring by means of methylene bridge.
  • The vitamin is converted to its active coenzyme form by addition of two phosphate groups, with the help of ATP.
  • The biologically active form of Vitamin B1 is Thiamine pyrophosphate (TPP).
  • It is catalyzed by Thiamine pyrophospho-transferase.
  • Thiamine pyrophosphate serves as a coenzyme in the …

For Complete lecture plz visit the lesson in Biochemistry I, then click curriculum tab in Vitamins

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