Prolactin (PRL) secreted by lactotropic cells of adenohypophysis is under the control of hypothalamus
Lactotrope hyperplasia is induced by estrogen (during last two trimesters of pregnancy).
Its secretion is primarily controlled by inhibitory effect of dopamine and GABA.
Its release is stimulated by TRH and vasoactive intestinal peptide (VIP).
It controls the initiation and maintenance of lactation.
The Prolactin secretion is pulsatile; highest levels during rapid eye movement sleep and peak serum level occurs between 04:00–06:00 hours.
Prolactin stimulates lactation on estrogen primed breast. It increases synthesis of milk protein and fat.
Hyperprolactinemia is a cause of infertility in females. Secretion of Prolactin is stimulated by TRH and inhibited by PIF
The main function of Prolactin
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